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@#Including gut microbiota and oral microbiota, various microorganisms in different human ecosystem constitute the human microbiota, which play an important role in human metabolism, immunity and maintaining microecological homeostasis. Abnormal changes in gut microbiota known as dysbiosis may lead to metabolic abnormalities and inflammatory changes, which are closely related to disease states including hypertension, diabetes, inflammatory bowel disease, and autoimmune diseases. The main cause of coronary artery disease is coronary atherosclerosis, a chronic and progressive inflammatory disease. Many evidences have shown that there is a correlation between gut microbiota and coronary artery disease. Therefore, we aim to review the relationship between gut microbiota and coronary artery disease, and discuss the possible research directions and application prospects.
ABSTRACT
Epigenetic modification includes DNA methylation, histone modification, non-coding RNA, etc., and is crucial in determining gene expression. A growing number of recent studies have shown that epigenetic regulation may play a central role in the pathogenesis of sepsis. Due to its explicit mechanism and relatively mature technic, DNA methylation has received extensive attention in sepsis-related researches. By examining recent studies on septic DNA methylation mechanism, this review elucidates the key role in sepsis occurrence and progression that DNA methylation plays from etiology, immunology and other aspects, as well as its application potential in the diagnosis, prognosis and treatment of sepsis before pointing out the direction for further research.
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Objective@#To study the clinical outcomes of anatomical hepatectomy combined with intraoperative choledochoscopy in treatment of complicated hepatolithiasis.@*Methods@#The clinical data of 176 patients with complicated hepatolithiasis who underwent operation at the Department of General Surgery of No.960 Hospital of PLA from May 2005 to July 2015 were analyzed retrospectively. The data included general data, clinical manifestations, types of stones, operative methods, postoperative complications and follow-up.@*Results@#There was no perioperative death. The postoperative complications which occurred in 31 patients (17.6%) included lung infection, intra-abdominal infection, bile leakage, and liver failure. Eighteen patients (10.2%) were found to have residual stones. After a follow-up which ranged from 1 to 3 years, 152 patients (94.4%) had good clinical outcomes. Recurrent stones were found in 12 patients (7.5%).@*Conclusion@#Anatomical hepatectomy combined with intraoperative choledochoscopy improved operative outcomes in patients with complicated hepatolithiasis and decreased residual stone and recurrence rates.
ABSTRACT
Objective To study the clinical outcomes of anatomical hepatectomy combined withintraoperative choledochoscopy in treatment of complicated hepatolithiasis.Methods The clinical data of176 patients with complicated hepatolithiasis who underwent operation at the Department of General Surgeryof No.960 Hospital of PLA from May 2005 to July 2015 were analyzed retrospectively.The data includedgeneral data,clinical manifestations,types of stones,operative methods,postoperative complications andfollow-up.Results There was no perioperative death.The postoperative complications which occurred in 31patients (17.6％) included lung infection,intra-abdominal infection,bile leakage,and liver failure.Eighteen patients (10.2％) were found to have residual stones.After a follow-up which ranged from 1 to 3years,152 patients (94.4％) had good clinical outcomes.Recurrent stones were found in 12 patients(7.5％).Conclusion Anatomical hepatectomy combined with intraoperative choledochoscopy improvedoperative outcomes in patients with complicated hepatolithiasis and decreased residual stone and recurrencerates.